T cell immunoreceptor with lg and ITIM domains (TIGIT) is a recently identified immune checkpoint protein expressed on Natural Killer cells (NK) and T cells. TIGIT is an inhibitory receptor which controls the immune activity by competing with activating receptor CD226 (also called DNAM-1) for ligand binding. This on and off switch of TIGIT and DNAM-1 corresponds with CTLA4 and CD28, making it a potential target for anti-tumor therapy.
CD112 (Nectin-2 or PVRL2) and CD155 (PVR) are co-ligands of DNAM-1 and TIGIT, while CD113 (Nectin-3 or PVRL3) only binds with TIGIT. The affinity between various ligands and receptors can differ. The binding between CD155 and TIGIT is stronger than that between CD113 or CD112 and TIGIT.
ACROBiosystems brings an extensive collection of recombinant proteins from TIGIT signaling axis. Besides the widely used Fc and His-labeled proteins, the company also brings multiple pre-biotinylated proteins such as Biotinylated Human CD155/PVR Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD5-H82F6); Biotinylated Human TIGIT, Avi Tag (Avitag™) (Cat. No.TIT-H82E5); Biotinylated Human Nectin-2/CD112 Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD2-H82F8).
Product Highlight
Immobilized Human CD155, Fc Tag (Cat. No.CD5-H5251) at 10 μg/mL (100 μL/well) can bind Biotinylated Human TIGIT, His Tag (Cat. No.TIT-H82E5) with a linear range of 0.08–0.31 μg/mL (QC tested).
TIGIT Product List
| Cat. No. |
Species |
Product Description |
Structure |
TIT-H82E5
(Biotin-labeled) |
 |
Biotinylated Human TIGIT Protein, Avi Tag |
 |
TIT-H82F1
(Biotin-labeled) |
|
Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag |
 |
| TIT-C5223 |
 |
Cynomolgus / Rhesus macaque TIGIT Protein |
 |
| TIT-C5254 |
|
Cynomolgus / Rhesus macaque TIGIT Protein, Fc Tag |
 |
| TIT-M52E6 |
 |
Mouse TIGIT Protein |
 |
| TIT-M5257 |
|
Mouse TIGIT Protein, Fc Tag |
 |
| TIT-R5258 |
 |
Rat TIGIT Protein, Fc Tag |
 |
| TIT-R5259 |
 |
Rabbit TIGIT Protein, Fc Tag |
 |
| TIT-H52H3 |
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Human TIGIT Protein |
 |
| TIT-H5253 |
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Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin |
 |
| TIT-H5254 |
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Human TIGIT Protein, Fc Tag |
 |
Other Relevant Products
| Molecule |
Cat. No. |
Species |
Product Description |
Structure |
| CD155 |
CD5-H82F6 |
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Biotinylated Human CD155 / PVR Protein, Fc, Avi Tag |
 |
| CD112 |
CD2-H82F8 |
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Biotinylated Human Nectin-2 / CD112 Protein, Fc, Avi Tag |
 |
| CD113 |
PV3-H82F3 |
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Biotinylated Human Nectin-3 / CD113 Protein, Fc, Avi Tag |
 |
| DNAM-1 |
DN1-H82F9 |
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Biotinylated Human DNAM-1 / CD226 Protein, Fc, Avi Tag |
 |
References
- Yu X, et al., 2009, Nat. Immunol. 10:48–57.
- Stengel KF, et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109:5399–5404.
- Lozano E, et al., 2012, J. Immunol. 188:3869–3875.
About ACROBiosystems 
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ACROBiosystems is a cornerstone enterprise of the pharmaceutical and biotechnology industries. Their mission is to help overcome challenges with innovative tools and solutions from discovery to the clinic. They supply life science tools designed to be used in discovery research and scalable to the clinical phase and beyond. By consistently adapting to new regulatory challenges and guidelines, ACROBiosystems delivers solutions, whether it comes through recombinant proteins, antibodies, assay kits, GMP-grade reagents, or custom services. ACROBiosystems empower scientists and engineers dedicated towards innovation to simplify and accelerate the development of new, better, and more affordable medicine.
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