T cell Immunoreceptor with lg and ITIM Domains Signaling Axis

T cell immunoreceptor with lg and ITIM domains (TIGIT) is a recently identified immune checkpoint protein expressed on Natural Killer cells (NK) and T cells. TIGIT is an inhibitory receptor which controls the immune activity by competing with activating receptor CD226 (also called DNAM-1) for ligand binding. This on and off switch of TIGIT and DNAM-1 corresponds with CTLA4 and CD28, making it a potential target for anti-tumor therapy.

TIGIT Signaling Axis

CD112 (Nectin-2 or PVRL2) and CD155 (PVR) are co-ligands of DNAM-1 and TIGIT, while CD113 (Nectin-3 or PVRL3) only binds with TIGIT. The affinity between various ligands and receptors can differ. The binding between CD155 and TIGIT is stronger than that between CD113 or CD112 and TIGIT.

ACROBiosystems brings an extensive collection of recombinant proteins from TIGIT signaling axis. Besides the widely used Fc and His-labeled proteins, the company also brings multiple pre-biotinylated proteins such as Biotinylated Human CD155/PVR Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD5-H82F6); Biotinylated Human TIGIT, Avi Tag (Avitag™) (Cat. No.TIT-H82E5); Biotinylated Human Nectin-2/CD112 Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD2-H82F8).

Product Highlight

Immobilized Human CD155, Fc Tag (Cat. No.CD5-H5251) at 10 μg/mL (100 μL/well) can bind Biotinylated Human TIGIT, His Tag (Cat. No.TIT-H82E5) with a linear range of 0.08–0.31 μg/mL (QC tested).

Immobilized Human CD155, Fc Tag (Cat. No.CD5-H5251) at 10 μg/mL (100 μL/well) can bind Biotinylated Human TIGIT, His Tag (Cat. No.TIT-H82E5) with a linear range of 0.08–0.31 μg/mL (QC tested).

TIGIT Product List

Cat. No. Species Product Description Structure
TIT-H82E5
(Biotin-labeled)
Biotinylated Human TIGIT Protein, Avi Tag TIT-H82E5
TIT-H82F1
(Biotin-labeled)
Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag TIT-H82F1
TIT-C5223 Cynomolgus / Rhesus macaque TIGIT Protein TIT-C5223-STC1
TIT-C5254 Cynomolgus / Rhesus macaque TIGIT Protein, Fc Tag TIT-C5254-STC1
TIT-M52E6 Mouse TIGIT Protein TIT-M52E6-STC1
TIT-M5257 Mouse TIGIT Protein, Fc Tag TIT-M5257-STC1
TIT-R5258 Rat TIGIT Protein, Fc Tag TIT-R5258-STC1
TIT-R5259 Rabbit TIGIT Protein, Fc Tag TIT-R5259-STC1
TIT-H52H3 Human TIGIT Protein TIT-H52H3-STC1
TIT-H5253 Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin TIT-H5253-STC1
TIT-H5254 Human TIGIT Protein, Fc Tag TIT-H5254-STC1

Other Relevant Products

Molecule Cat. No. Species Product Description Structure
CD155 CD5-H82F6 Biotinylated Human CD155 / PVR Protein, Fc, Avi Tag CD5-H82F6-STC1
CD112 CD2-H82F8 Biotinylated Human Nectin-2 / CD112 Protein, Fc, Avi Tag CD2-H82F8-STC1
CD113 PV3-H82F3 Biotinylated Human Nectin-3 / CD113 Protein, Fc, Avi Tag PV3-H82F3-STC1
DNAM-1 DN1-H82F9 Biotinylated Human DNAM-1 / CD226 Protein, Fc, Avi Tag DN1-H82F9-STC1

References

  1. Yu X, et al., 2009, Nat. Immunol. 10:48–57.
  2. Stengel KF, et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109:5399–5404.
  3. Lozano E, et al., 2012, J. Immunol. 188:3869–3875.

About ACROBiosystems

ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process.

To respond to coronavirus pandemic, ACROBiosystems has developed SARS-CoV-2 antigens specifically designed and optimized for serological test kits, including Spike-derived antigen S1, RBD and Nucleocapsid protein. Proteins have been supplied to diagnostic companies in large quantity.


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Last updated: Jun 15, 2020 at 7:57 AM

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